WebDec 31, 2024 · Generic name: Chloramphenicol [ klor-am-FEN-i-kole ] Drug class: Miscellaneous antibiotics Medically reviewed by Drugs.com. Last updated on Aug 19, 2024. Uses Before taking Warnings Side effects Overdose Dosage Warning Very bad and sometimes deadly blood problems have happened with chloramphenicol. WebChloramphenicol is a broad-spectrum antimicrobial agent. It acts by inhibiting protein synthesis. Its high lipid solubility results in rapid absorption, a large volume of distribution, and accelerated penetration into almost all tissues. Aplastic anemia and bone marrow suppression are chloramphenicol's most serious adverse effects in humans.
Molecular basis of bacterial resistance to chloramphenicol and ...
Chloramphenicol is an antibiotic useful for the treatment of a number of bacterial infections. This includes use as an eye ointment to treat conjunctivitis. By mouth or by injection into a vein, it is used to treat meningitis, plague, cholera, and typhoid fever. Its use by mouth or by injection is only recommended when … See more The original indication of chloramphenicol was in the treatment of typhoid, but the presence of multiple drug-resistant Salmonella Typhi has meant it is seldom used for this indication except when the organism is known … See more Chloramphenicol is extremely lipid-soluble; it remains relatively unbound to protein and is a small molecule. It has a large apparent volume of distribution and … See more Chloramphenicol was first isolated from Streptomyces venezuelae in 1947 and in 1949 a team of scientists at Parke-Davis including Mildred Rebstock published their identification of the chemical structure and their synthesis. In 1972, Senator See more Although its use in veterinary medicine is highly restricted, chloramphenicol still has some important veterinary uses. It is currently considered the most useful treatment of … See more Aplastic anemia The most serious side effect of chloramphenicol treatment is aplastic anaemia. This effect is rare but sometimes fatal. … See more Chloramphenicol is a bacteriostatic agent, inhibiting protein synthesis. It prevents protein chain elongation by inhibiting the peptidyl transferase activity … See more Names Chloramphenicol is available as a generic worldwide under many brandnames and also under various … See more WebJan 23, 2024 · Chloramphenicol Resistance is a nonsusceptibility of bacteria to the action of CHLORAMPHENICOL, a potent inhibitor of protein synthesis in the 50S ribosomal subunit where amino acids are added... brockville country club
Package leaflet: Information for the user Chloramphenicol
WebLike all medicines, Chloramphenicol can cause side effects, although not everybody gets them. Some people find that their eyes sting or their sight is blurred immediately after … WebFeb 27, 2024 · sensitivity to light (photophobia) disturbed vision intense redness in one eye or both eyes Contact your optician immediately if you experience any of these symptoms. … WebHowever, the rampant use of ciprofloxacin gradually led to an increase in its minimum inhibitory concentration against S. enterica typhi. This threatened its therapeutic efficacy and resulted in the re-emergence of chloramphenicol-sensitive S. enterica typhi strains. brockville family nails