WebNov 17, 2024 · CTSB is required for ferroptosis suppression by extracellular albumin (A) LysoTracker Red, a marker for lysosomes, and self-quenched BSA (DQ-BSA) fluorescence in PaTu 8988T cells. ... (EMD Millipore, Cat# SLHV033RS), and stored in single-use aliquots at −80°C until use. For CTSB, CTSD, CTSL and ATG7 disruption, lentiviruses were … WebDec 17, 2024 · We and others previously demonstrated that ferroptosis is a type of lysosomal cell death associated with excessive autophagy [ [8], [9], [10] ], but the key mediator of this process is still poorly understood. In this study, we provide the first genetic evidence that cathepsin B (CTSB) is a mediator of ferroptosis by its activating DNA …
Signaling pathways and defense mechanisms of ferroptosis
WebDec 17, 2024 · Here, we show that the translocation of lysosomal cysteine protease cathepsin B (CTSB) into the nucleus is an important molecular event that mediates … WebAn overview of the critical roles and regulatory pathways of CatB in different types of PCD, and the possibility ofCatB as an attractive target in multiple diseases is discussed, to highlight future avenues for research. Cathepsin B (CatB), a cysteine protease, is primarily localized within subcellular endosomal and lysosomal compartments. It is involved in the … dwm high gpu usage intel
Ferroptosis: molecular mechanisms and health implications
WebAug 27, 2024 · Ferroptosis is a new form of regulated cell death based on the iron-dependent accumulation of excessive lipid peroxidation. Glutathione peroxidase 4 (GPX4) is the core regulator of ferroptosis by detoxifying cellular lipid peroxidation using glutathione as a cofactor. ... (CTSB) into the nucleus is an important molecular event that mediates ... WebJan 13, 2024 · Several studies have demonstrated that LMP and CTSB involved various cell death modes, including apoptosis, ferroptosis, and necrosis . Zhou et al. reported that the release of CTSB and CTSL from lysosome increased the expression of tBid, active caspase-3, and cytoplastic cytochrome C in oxygen and glucose deprivation model ( 33 ). WebFeb 6, 2024 · Appropriate exercise such as voluntary wheel-running can induce physiological cardiac hypertrophy. Notch1 plays an important role in cardiac hypertrophy; however, the experimental results are inconsistent. In this experiment, we aimed to explore the role of Notch1 in physiological cardiac hypertrophy. Twenty-nine adult male mice … crystal leviner